abstract：:Nitrofurnation is an antibacterial drug. It is used in the treatment of initial or recurrent urinary tract infections caused by susceptible organisms. The cyclic voltammogram of the drug in Britton-Robinson buffers (pH 2-11) exhibited a single well-defined cathodic peak at the hanging mercury drop electrode, that due ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hammam E

更新日期：2002-10-15 00:00:00

abstract：:Chrome azurol S (CAS) was tested as a spectrophotometric reagent for the determination of imipramine (IMP). It reacts in aqueous media with IMP forming pink-red, sparingly soluble in water ion association compound. This compound was quantitatively extracted with chloroform and the absorbance of organic phase was measu...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Starczewska B,Hałaburda P,Kojło A

更新日期：2002-10-15 00:00:00

abstract：:A new method for the determination of the active principle dexketoprofen (DKP) in a hydrogel using near infrared spectrometry was developed. A transflectance module allows the gel spectrum to be recorded with no sample pretreatment. Also, the PLS calibration method used allows low contents of the active principle in s...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Blanco M,Romero MA

更新日期：2002-10-15 00:00:00

abstract：:Five tricyclic antidepressants (TADs), desipramyne, nortriptyline, imipramine, doxepin and amitriptyline, were separated by using the N,N,N',N'-tetramethyl-1,3-butanediamine (TMBD) as additive in the background electrolyte solution. Because the tricyclic antidepressants are similar in structure, mass and pka values, t...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Dell'Aquila C

更新日期：2002-09-05 00:00:00

abstract：:A rapid and sensitive polarographic method was developed for qualitative as well as quantitative analysis of the neurotoxic contaminant benzaldehyde in Na-diclofenac injections and in benzyl alcohol used for parental formulations. A well-defined differential pulse (DP) polarographic peak or a sampled direct current (S...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kazemifard AG,Moore DE,Mohammadi A

更新日期：2002-09-05 00:00:00

abstract：:A simple and rapid spectrophotometric method with flow injection is proposed for determination of diphenhydramine hydrochloride in some single tertiary alkylamine pharmaceutical preparations (capsule and syrup). It is based on ion pair formation with bromocresol green in a pH 3 buffer which a yellow ion pair compound ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Tipparat P,Lapanantnoppakhun S,Jakmunee J,Grudpan K

更新日期：2002-08-22 00:00:00

abstract：:PGE-9509924 is a nonfluorinated quinolone and is active against a variety of susceptible and drug resistant bacteria in vitro and in animal infection models. A method for determining both enantiomers of PGE-9509924 in dog plasma has been developed. The enantiomers are derivatized with a chiral derivatizing agent, (-)-...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zoutendam PH,Canty JF,Martin MJ,Dirr MK

更新日期：2002-08-22 00:00:00

abstract：:The possibility has been investigated of applying derivative analysis to a classical enzymatic-spectrophotometric method for lecithin determination for the purpose of developing an analytical direct method that does not require long pretreatment of the test sample even in the case of turbid samples. Several samples of...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Campanella L,Magrì AL,Sorbo A,Tomassetti M

更新日期：2002-08-01 00:00:00

abstract：:An analytical GC-MS method based on nonpolar fused silica capillary column was developed to analyze the lipophilic constituents, mainly alkamides, from the root extracts of Echinacea purpurea (L.) Moench. In particular, the proposed method was applied to evaluate the phytochemical impacts of cucumber mosaic cucumoviru...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hudaib M,Fiori J,Bellardi MG,Rubies-Autonell C,Cavrini V

更新日期：2002-08-01 00:00:00

abstract：:The validation of a microbiological assay, applying the cylinder-plate method, for the determination of the antibiotic azithromycin is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, azithromycin at concentrations ranging from 0.1 to 0.4 microgml(-1) could be measured in capsules and su...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Breier AR,Garcia CV,Oppe TP,Steppe M,Schapoval EE

更新日期：2002-07-31 00:00:00

abstract：:A spectrophotometric method for the determination of lisinopril (LN) in single and multicomponent tablets also containing hydrochlorothiazide (HCT), based on the derivatization reaction with 1-fluoro-2,4-dinitrobenzene (FDNB, Sanger reagent) is described. Aqueous solutions of LN (4.5-27.2 x 10(-5) M) react with FDNB (...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Paraskevas G,Atta-Politou J,Koupparis M

更新日期：2002-07-31 00:00:00

abstract：:A reversed phase high-performance liquid chromatographic method with detection at 220 nm was developed and validated for the determination of piperacillin, I, and tazobactam, II, in Tazocin injectable powder. Acetaminophen was used as internal standard. A Hypersil BDS RP-C(18) column (250 x 4.6 mm), 5 microm particle ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Marselos SC,Archontaki HA

更新日期：2002-07-31 00:00:00

abstract：:A micellar electrokinetic chromatographic (MEKC) method was developed for the quantification of lovastatin and simvastatin, cholesterol lowering agents in pharmaceutical dosage forms. Lovastatin and simvastatin were separated using an electrolyte system consisting of 12% acetonitrile (v/v) in 25 mM sodium borate buffe...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Srinivasu MK,Raju AN,Reddy GO

更新日期：2002-07-20 00:00:00

abstract：:A kinetic study of the hydrolytic decomposition of droxicam was carried out in order to establish the possible pharmacological action of the drug in the organism of the human being. The electrochemical technique used was scan cyclic voltammetry on a HMDE, giving a well-defined peak. Due to the insolubility of droxicam...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Acuña JA,de la Fuente C,Vázquez MD,Tascón ML,Gómez MI,Mata F,Sánchez-Batanero P

更新日期：2002-07-20 00:00:00

abstract：:A method for the determination of 4-aminophenol as an impurity in paracetamol (N-(4-hydroxyphenyl)-acetamide) by proton nuclear magnetic resonance ((1)H-NMR) spectroscopy has been developed. The (13)C-satellite from the protons in the ortho position from the hydroxyl group in paracetamol was used as an internal standa...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Forshed J,Andersson FO,Jacobsson SP

更新日期：2002-07-01 00:00:00

abstract：:A method for the analysis of aqueous samples of isosorbide-5-mononitrate (5-ISMN) is presented. It is based on packed column supercritical fluid chromatography (SFC) using 20% of 2-propanol in carbon dioxide as the mobile phase and a diol silica column as the stationary phase. Using the described conditions it is poss...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Gyllenhaal O,Hulthe J

更新日期：2002-06-20 00:00:00

abstract：:A first-derivative spectrophotometric method for the determination of irbesartan (IRB) alone and in the presence of hydrochlorothiazide (HCT) is described. Measurements are made at the zero-crossing wavelength at 263.0 nm for IRB. The calibration graph was linear over the range 1.0-12.0 mg l(-1) of IRB, detection limi...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Albero I,Ródenas V,García S,Sánchez-Pedreño C

更新日期：2002-06-20 00:00:00

abstract：:A reversed phase ion-pair liquid chromatographic method using a base deactivated column and pulsed electrochemical detection on a gold electrode is described. It allows the separation of a mixture of spectinomycin sulfate, lincomycin hydrochloride and their related substances. A step gradient was necessary to obtain a...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Szúnyog J,Adams E,Liekens K,Roets E,Hoogmartens J

更新日期：2002-06-20 00:00:00

abstract：:Most drugs are excreted into breast milk to some extent and are bioavailable to the infant. The ability to predict the approximate amount of drug that might be present in milk from the drug structure would be very useful in the clinical setting. The aim of this research was to simplify and upgrade the previously devel...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Agatonovic-Kustrin S,Ling LH,Tham SY,Alany RG

更新日期：2002-06-20 00:00:00

abstract：:Drugs may be metabolised to reactive electrophilic species that spontaneously react with proteins. The presence of such drug-protein adducts has been associated with drug toxicity. In this study, the reactivity of the major metabolite of naproxen--the 1-beta-O-glucuronide (Nap-GlcU)--was compared to the corresponding ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Olsen J,Bjørnsdottir I,Tjørnelund J,Honoré Hansen S

更新日期：2002-06-20 00:00:00

abstract：:A simple and rapid capillary electrophoresis method with UV detection was developed and validated for the determination of rufloxacin hydrochloride in coated tablets. An experimental design strategy (Doehlert design and desirability function) allowed the analytical parameters to be simultaneously optimized in order to...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Furlanetto S,Orlandini S,Porta EL,Coran S,Pinzauti S

更新日期：2002-06-15 00:00:00

abstract：:A rapid, selective and stability indicating high performance liquid chromatographic method was developed and validated for the estimation of venlafaxine in pharmaceutical dosage forms. The analysis was done on a Spherisorb C8 (4.6 x 250 mm, 5 microm) column. The mobile phase consisted of acetonitrile:sodium dihydrogen...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Makhija SN,Vavia PR

更新日期：2002-06-15 00:00:00

abstract：:The interactions between a nonsteroidal anti-inflammatory drugs, oxyphenbutazone (OPB), with two cyclodextrins, beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), have been studied in an aqueous medium and in the solid state. Differential scanning calorimetry, hot stage microscopy, thermogravimetric analys...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Veiga MD,Merino M

更新日期：2002-06-01 00:00:00

abstract：:The development of a new HPLC-UV diode array procedure applied to follow the hydrolytic degradation of two well-known 4-nitrophenyl-1,4-dihydropyridine derivatives, nitrendipine and nisoldipine is reported. Hydrolysis of each drug were carried out in ethanol/Britton-Robinson buffer at different pHs, stored into amber ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Alvarez-Lueje A,Sturm J,Squella JA,Núñez-Vergara LJ

更新日期：2002-06-01 00:00:00

abstract：:SU101 or leflunomide, has been studied extensively because of its anti-cancer and immunomodulating properties. The parent isoxazole compound is converted in vitro and metabolized in vivo to an open ring isomeric form, SU0020. Several pharmacological activities have been reported for the parent and metabolite compounds...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhang Q,Pang WL,Chen H,Cherrington J,Lipson K,Antonian L,Shawver LK

更新日期：2002-05-15 00:00:00

abstract：:A differential pulse polarographic method is described for detection and trace determination of benzophenone (the main impurity) in phenytoin powder. The method depends upon the polarographic activity of benzophenone in Britton-Robinson buffer pH 5.6. The limit of detection was found to be 2.5 x 10(-6) microg ml(-1). ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Razak OA,Gazy AA,Wahbi AM

更新日期：2002-05-15 00:00:00

abstract：:Capillary isotachophoresis (ITP) with conductimetric detection has been used for separating and determining bopindolol (I) in commercial mass-produced pharmaceutical preparations. The optimised operational electrolyte system consisted of 5 mM potassium picolinate and 5 mM picolinic acid (leading electrolyte, LE; pH 5....

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Urbánek M,Pospísilová M,Polásek M

更新日期：2002-05-15 00:00:00

abstract：:This paper proposes a method for the validation of chromatography systems in which many experiments to estimate SD or RSD are difficult or impossible to carry out because of time, cost, etc. HPLC systems with UV-Vis and fluorescence detectors and GC-MS system for bisphenol-A leached from hemodialyzers are taken as an ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hayashi Y,Matsuda R,Haishima Y,Yagami T,Nakamura A

更新日期：2002-05-15 00:00:00

abstract：:Four analytical methods have been developed for the quality control of tablets containing mirtazapine: spectrophotometry, spectrofluorimetry, high performance liquid chromatography (HPLC) and capillary zone electrophoresis (CZE). All the methods only require a simple extraction procedure of mirtazapine from the tablet...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Labat L,Dallet P,Kummer E,Dubost JP

更新日期：2002-04-15 00:00:00

abstract：:Twenty-seven highly diversified pharmaceutical compounds were used as a test set to evaluate matrix effects from microsomal media on LC/MS analyses. The individual effects of Tris buffer, NADPH and microsomes on ESI response were investigated. Direct flow injection MS/MS analysis, using no sample preparation or HPLC s...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zheng JJ,Lynch ED,Unger SE

更新日期：2002-04-15 00:00:00

abstract：:A miniaturized immunoassay for human interleukin-13 (IL-13) using homogeneous time-resolved fluorescence (HTRF) has been developed. In this assay, IL-13 which was secreted from NK3.3 cells stimulated with interleukin-2 (IL-2) was detected by measuring the time-resolved fluorescence after adding a mixture of three reag...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Enomoto K,Araki A,Nakajima T,Ohta H,Dohi K,Préaudat M,Seguin P,Mathis G,Suzuki R,Kominami G,Takemoto H

更新日期：2002-04-01 00:00:00

abstract：:Recently direct plasma injection LC/MS/MS technique has been increasingly used in pharmaceutical research and development due to the demand for higher throughput of sample analyses. In this work, two on-line extraction methods including high flow LC/MS/MS and high flow column switching LC/MS/MS were investigated. The ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zeng H,Wu JT,Unger SE

更新日期：2002-03-01 00:00:00

abstract：:A novel cimetidine ion-selective electrode is prepared, characterized and used in pharmaceutical analysis. The electrode incorporates PVC-membrane with cimetidine-phospohotungstate ion pair complex. The electrode exhibits a Nernstian response for cimetidine in the concentration range 1.0 x 10(-5)-1.0 x 10(-2) M with a...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Shamsipur M,Jalali F,Haghgoo S

更新日期：2002-03-01 00:00:00

abstract：:The electrochemical reduction of meloxicam has been studied at a mercury electrode using various electrochemical methods in aqueous solutions over a wide pH range. The reduction of the drug produced a single reduction step in acidic media, whereas in slightly acidic and neutral media two reduction steps were observed....

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Beltagi AM,Ghoneim MM,Radi A

更新日期：2002-02-01 00:00:00

abstract：:Applications of capillary electrophoresis (CE) for analysis of phytochemical substances (e.g. flavonoids, alkaloids, terpenoids, phenolic acid, quinones and coumarins) are reviewed. For example, CE analysis of sixteen tea ingredients were achieved within 10 min with the good precision (RSDs% <1% for intra-day and 2% f...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Suntornsuk L

更新日期：2002-02-01 00:00:00

abstract：:This paper deals with the chiral separation of optical isomers of beta-methyl-amino acids by CE and HPLC using the principle of ligand-exchange. Capillary zone electrophoresis was carried out using Cu(II) complexes of L-4-hydroxyproline (L-4-Hypro), N-(2-hydroxypropyl)-L-4-hydroxyproline (HP-L-4-Hypro) and N-(2-hydrox...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Grobuschek N,Schmid MG,Tuscher C,Ivanova M,Gübitz G

更新日期：2002-01-15 00:00:00

abstract：:An analytical method was developed for the determination of the enantiomers of felodipine, a dihydropyridine-type calcium antagonist, in human blood plasma. Felodipine was extracted from plasma using toluene as extraction solvent. The enantiomers were separated on a cellulose tris(4-methyl benzoate) stationary phase (...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lindmark B,Ahnoff M,Persson BA

更新日期：2002-01-15 00:00:00

abstract：:While capillary electrophoresis has been established as a major enantioseparation technique within the last decade, the potential of capillary electrochromatography is still studied extensively. This review summarizes recent applications of electromigration techniques with regard to the enantioseparation of chiral dru...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Scriba GK

更新日期：2002-01-15 00:00:00

abstract：:In early safety assessment studies with the experimental anti-neoplastic drug XP315, a toxic reaction was observed in dogs immediately after intravenous (iv) infusion. The reaction was characterized by severe erythema around the ears, eyes, face and body; ocular hyperemia; head shaking; swelling around the eyes, face,...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Sigvardson KW,Adams SP,Barnes TB,Blom KF,Fortunak JM,Haas MJ,Reilly KL,Repta AJ,Nemeth GA

更新日期：2002-01-01 00:00:00

abstract：:The stability of the new chemical synthetic enaminone derivative (E118) was investigated using a stability-indicating high-performance liquid chromatography (HPLC) procedure. The examined samples were analyzed using a chiral HSA column and a mobile phase (pH 7.5) containing n-octanoic acid (5 mM), isopropyl alcohol an...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Abdel-Hamid ME,Edafiogho IO,Hamza HM

更新日期：2002-01-01 00:00:00